姚后宗

讲师 | 博士

发布时间：2023-12-03来源：国家淡水鱼加工技术研发专业中心访问次数：12

  1. 个人简介

姓名：姚后宗

职称：讲师

学位：博士

硕导/博导：生物与医药专业硕导

籍贯：江西省乐安县

  1. 学习经历

2017.06– 2021.10，香港城市大学，化学，博士

2012.09– 2015.06，苏州大学，药物化学，硕士

2008.09– 2012.06，苏州大学，药学，学士

  1. 工作经历

2022.04– 今，江西师范大学，健康学院，讲师

2015.12– 2017.05，香港浸会大学，中医药学院，（高级）研究助理

  1. 研究兴趣

铂类金属抗癌药的合成、生物活性与机理研究

  1. 主持的科研项目

江西省高层次和急需紧缺海外人才引进计划（20223BCJ25009），30万，在研

江西省自然科学基金青年基金项目（20232BAB216132）10万，在研

江西省教育厅科学技术研究项目重点项目（GJJ2200308），5万，在研

江西师范大学高层次人才引进优秀海归启动经费（12021881），50万，在研

  1. 代表性论文、论著和专利

  1. QingtingZeng, Hao Cui, HouzongYao,*Tao Yuan.* FiveSesquiterpenes from Paraconiothyrium sp. and TheirAnti-inflammatoryActivity.Chem.Biodiversity2023,e202300477.

  2. Zhiqin Deng,†HouzongYao,†Zhigang Wang, GuangyuZhu.Platinumanticancer drugs: Targeting and delivery.InBioinorganicChemistry and Homogeneous Biomimetic Inorganic Catalysis;Pecoraro,V. L.; Guo, Z.; in Comprehensive Inorganic Chemistry III; Reedijk,J.,Poeppelmeier,K. R., Eds.; Vol. 2, pp 808–846. Oxford: Elsevier. 2023.

  3. Houzong Yao,GuangyuZhu.BloodComponents as Carriers for Small-Molecule PlatinumAnticancerDrugs.ChemMedChem.2022,e202200482.

  4. Houzong Yao,†Zhigang Wang,†Na Wang, Zhiqin Deng, Gongyuan Liu, Jianghong Zhou, Shu Chen, JiahaiShi, Guangyu Zhu.Enhancingcirculation and tumor accumulation of carboplatin via anerythrocyte-anchored prodrug strategy.Angew.Chem. Int. Ed.2022,e202203838.

  5. Houzong Yao,Guangyu Zhu.Aplatinum-based fluorescent "turn on" sensor to decipherthe reduction of platinum(IV) prodrugs.DaltonTrans.2022,51, 5394−5398.

  6. Houzong Yao,Yuliana F. Gunawan, Gongyuan Liu, Man-Kit Tse, Guangyu Zhu.Optimizationof axial ligands to promote the photoactivation of BODIPY-conjugatedplatinum (IV) anticancer prodrugs.DaltonTrans.2021,50,13737−13747.

  7. Houzong Yao,Shu Chen, Zhiqin Deng, Man-Kit Tse, Yudai Matsuda, Guangyu Zhu.BODI-Pt,a green-light-activatable and carboplatin-based platinum (IV)anticancer prodrug with enhanced activation and cytotoxicity.Inorg.Chem.2020,59,11823−11833.

  8. Houzong Yao,Zoufeng Xu, Cai Li, Man-Kit Tse, Zixuan Tong, Guangyu Zhu.Synthesisand cytotoxic study of a platinum (IV) anticancer prodrug withselectivity toward luteinizing hormone-releasing hormone (LHRH)receptor-positive cancer cells.Inorg.Chem.2019,58,11076−11084.

  9. Shuaijian Ni,†HouzongYao,†Lili Wang, Jun Lu, Feng Jiang, Aiping Lu, Ge Zhang.Chemicalmodifications of nucleic acid aptamers for therapeutic purposes.Int.J. Mol. Sci.2017,18,1683.

  10. Houzong Yao,Feng Jiang, Aiping Lu, Ge Zhang.Methodsto design and synthesize antibody-drug conjugates (ADCs).Int.J. Mol. Sci. 2016,17,194.

  11. Houzong Yao,Fengyou Liu, Jinglei Chen, Yan Li, Jinhao Cui, Chunhua Qiao.Antischistosomalactivity of N,N'-arylurea analogs against Schistosoma japonicum.Bioorg.Med. Chem. Lett.2016,26,1386−1390.

  12. 姚后宗，尹伟，陈晶磊，乔春华.一种氟代丁酸腺苷衍生物的合成.有机化学.2014,34,1222−1226.

  1. 联系方式

微信：yhz54242056

邮箱：yaohz@jxnu.edu.cn